Ipamorelin

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Ipamorelin

Price range: $32.00 through $60.00 / 10 Vials

Ipamorelin is a selective growth-hormone secretagogue that binds to the growth-hormone secretagogue receptor type 1a (GHS-R1a) without significant activity at ghrelin O-acyltransferase or other pituitary hormone receptors. In in vitro and preclinical rodent models, it’s employed to dissect growth-hormone axis dynamics and downstream anabolic, lipolytic, and osteoanabolic pathways.

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Product Details

Amino Acid Sequence：Aib–His–D-2Nal–D-3Phe–Lys–NH₂
Molecular Formula：C₃₆H₄₉N₉O₅
Molecular Weight：711.82 g/mol
PubChem CID：16041794
CAS Number：170851-70-4
Vial Size：3ml
Contents：Lyophilized powder, white/off-white color

Additional information

Size

10mg, 5mg, 2mg
Mechanism of action

GHS-R1a Agonism & GH Secretion
Ipamorelin selectively activates GHS-R1a on somatotrophs, coupling via Gαq/11 to PLCβ → IP₃/DAG signaling, triggering Ca²⁺-dependent exocytosis of growth hormone—yielding pulsatile release without concomitant ACTH or cortisol secretion.
Anabolic & Lipolytic Signaling
Elevated GH induces hepatic IGF-1 production, which engages the IGF-1R/PI3K/Akt pathway in muscle and adipose tissue, promoting protein synthesis and adipocyte lipolysis.
Osteoanabolic Effects
GH/IGF-1 axis activation upregulates Runx2 and osterix in osteoblasts via JAK2/STAT5 signaling, enhancing bone matrix deposition and mineralization.
Storage & handling

Storage:Store the lyophilized vial in a cool, dry area protected from direct sunlight.

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