MOTS-C

Price range: $74.00 through $240.00 / 10 Vials

MOTS-C (Mitochondrial ORF of the Twelve S rRNA type-C) is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene. Identified in 2015, it functions as a mitochondrial-derived peptide (MDP) involved in regulating metabolic homeostasis. In preclinical and early human studies, MOTS-C enhances insulin sensitivity, promotes lipid and glucose metabolism, and increases exercise capacity. It is supplied as a high-purity lyophilized powder for use in laboratory research.

Product Details

Amino Acid Sequence:Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Formula:C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight:2174.6 g/mol
PubChem CID:146675088
CAS Number:1627580-64-6
Contents:Lyophilized powder, white/off-white color

Additional information

Size

40mg, 20mg, 10mg

Mechanism of action

AMPK Activation
MOTS-C increases levels of AICAR and stimulates AMPK, leading to enhanced glucose uptake and fatty-acid oxidation.
Insulin Sensitivity
Improves glucose tolerance and insulin action in diet-induced obese mice; correlates with insulin signaling enhancement in skeletal muscle.
Exercise Mimetic Role
Circulating MOTS-C rises in humans during acute exercise; in mice, administration increases exercise performance and stress adaptation.
Cytoprotection
Acts as a “mitokine,” transmitting mitochondrial stress signals and promoting cellular resilience.

Storage & handling

Storage:Store the lyophilized vial in a cool, dry area protected from direct sunlight.

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