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AOD9604

Price range: $110.00 through $196.00 / 10 Vials

AOD-9604 is a synthetic hexadecapeptide fragment corresponding to residues 176–191 of human growth hormone. It selectively stimulates adipocyte lipolysis by upregulating β₃-adrenergic receptors and inhibiting lipoprotein lipase, while sparing IGF-1 receptor activation. The peptide demonstrates oral bioavailability and reduces weight gain in rodent models without altering blood glucose levels.

Size

10mg
5mg

Clear

SKU: N/A Categories: Repair & Anti-Inflammatory, Weight & Glycemic Management

Product Details
Additional information

Product Details

Amino Acid Sequence

Tyr–Leu–Arg–Ile–Val–Gln–Cys–Arg–Ser–Val–Glu–Gly–Ser–Cys–Gly–Phe

Molecular Formula

C₇₈H₁₂₃N₂₃O₂₃S₂

Molecular Weight

1815.1 g/mol

PubChem CID

71300630

CAS Number

221231-10-3

Lyophilized powder, white/off-white color

Additional information

Size	10mg, 5mg
Mechanism of action	β₃-Adrenergic Receptor–Mediated Lipolysis AOD-9604 upregulates β₃-adrenergic receptor expression in adipocytes, increasing intracellular cAMP and activating hormone-sensitive lipase for fatty-acid mobilization Lipoprotein Lipase Inhibition The peptide directly inhibits adipose tissue lipoprotein lipase activity, shifting the balance toward enhanced fat breakdown over storage. Oral Bioavailability In obese Zucker rats, once-daily oral dosing (500 µg/kg) achieved systemic exposure and a >50% reduction in weight gain, demonstrating effective gastrointestinal absorption
Storage & handling	Storage:Store the lyophilized vial in a cool, dry area protected from direct sunlight.