Price range: $56.00 through $186.00 / 10 Vials
TB-500 (TB500 or Thymosin β-4 Active Fragment) is a synthetic heptapeptide corresponding to the N-terminal actin-binding domain of endogenous Thymosin β-4. It modulates cytoskeletal dynamics by sequestering G-actin monomers and promoting localized F-actin polymerization, thereby enhancing cellular motility and migration. TB-500 upregulates angiogenic growth factors (e.g., VEGF, FGF-2) via MAPK/ERK and PI3K/Akt signaling, driving neovascularization in ischemic or injured tissues. Concurrently, it attenuates pro-inflammatory cytokines (TNF-α, IL-6) through NF-κB inhibition, creating a reparative microenvironment. In in vitro and rodent models, these combined actions support accelerated tissue regeneration, angiogenesis, and reduced inflammatory damage.
Product details
Amino Acid Sequence：Ac-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ)
Molecular Formula：C₃₈H₆₈N₁₀O₁₄
Molecular Weight：889.02 g/mol
PubChem CID：62707662
CAS Number：885340-08-9
Contents：Lyophilized powder, white/off-white color
| Size | 10mg, 5mg, 2mg |
|---|---|
| Mechanism of action | Actin Sequestration & Polymerization Regulation |
| Storage & handling | Storage:Store the lyophilized vial in a cool, dry area protected from direct sunlight. |
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