GHK-CU

Price range: $24.00 through $34.00 / 10 Vials

GHK-Cu (known as Copper Peptide) is a triaminopeptide complexed with Cu²⁺ that modulates gene expression—upregulating genes involved in extracellular matrix synthesis (e.g., COL1A1, ELN) and downregulating matrix metalloproteinases (e.g., MMP1). It activates TGF-β and PDGF pathways in dermal fibroblasts, enhances antioxidant defenses via Nrf2-driven transcription, and influences angiogenic signaling through VEGF induction. In in vitro and rodent models, these combined effects accelerate tissue regeneration, dermal remodeling, and anti-inflammatory responses.

Product Details

Amino Acid Sequence:Gly-His-Lys
Molecular Formula:C₁₄H₂₂N₆O₄Cu
Molecular Weight:340.08 g/mol
PubChem CID:439533
CAS Number:495155-66-3
Contents:Lyophilized powder, blue color

Additional information

Size

100mg, 50mg

Mechanism of action

Extracellular Matrix Remodeling
GHK-Cu upregulates COL1A1, COL3A1, and ELN expression while downregulating MMP1 and MMP9, resulting in enhanced dermal fibroblast-mediated matrix deposition.
Growth Factor Activation
Activates latent TGF-β and increases PDGF-BB release, driving fibroblast proliferation and myofibroblast differentiation for wound contraction.
Antioxidant & Anti-Inflammatory Signaling
Induces Nrf2 nuclear translocation, elevating SOD and catalase activity, and inhibits NF-κB, reducing TNF-α and IL-1β production.
Angiogenesis Promotion
Increases VEGF and FGF-2 secretion from endothelial cells, enhancing capillary sprouting and neovascularization in repair sites

Storage & handling

Storage:Store in a cool, dry area protected from direct sunlight